No |
Clinical Trial |
Status |
Clinical Trial Gov |
1 |
SOHO-02
A Phase 3 open-label, randomized, active-controlled, multicenter trial to evaluate the efficacy and safety of orally administered BAY 2927088 compared with standard of care as a first-line therapy in patients with locally advanced or metastatic non- small cell lung cancer (NSCLC) with HER2-activating mutations. |
Active (Recruiting) |
A Study to Learn More About How Well BAY 2927088 Works |
2 |
ATORG001
A prospective, molecular profiling study of mutational genes in Asian patients with Non-Small Cell Lung Cancer. (Non-interventional study). |
Active (Recruiting) |
Study of mutational genes in Asian patients |
3 |
ATORG004
Plasma Molecular Profiling in ALK inhibitor resistant non-small cell lung cancer |
Active (Recruiting) |
Plasma Molecular Profiling in ALK inhibitor resistant non-small cell lung cancer |
4 |
PACIFIC-8
A Phase 3, Randomised, Double blind, Placebo controlled, Multicentre, International Study of Durvalumab plus Domvanalimab (AB154) in Participants with Locally Advanced (Stage III), Unresectable Non small Cell Lung Cancer Whose Disease has not Progressed Following Definitive Platinum based Concurrent Chemoradiation Therapy (PACIFIC-8) |
Active (Recruiting) |
Study of Durvalumab plus Domvanalimab (AB154) in Participants with Locally Advanced |
5 |
MK3475-D46
Study of Pembrolizumab (MK-3475) Monotherapy Versus Sacituzumab Govitecan in Combination With Pembrolizumab for Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% |
Active (Recruiting) |
Study of Pembrolizumab (MK-3475) Monotherapy Versus Sacituzumab Govitecan |
6 |
Paloma-2
A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer |
Active (Recruiting) |
Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors |
7 |
BGB-LC-201
A Study of Tislelizumab in Combination With Investigational Agents in Participants With Non-Small Cell Lung Cancer |
Active (Recruiting) |
Study of Tislelizumab in Combination With Investigational Agents |
8 |
Jimmy Lung
A randomized, double-blind, parallel-group study to compare efficacy, safety, and immunogenicity of GME751 (proposed pembrolizumab biosimilar) and EU-authorized Keytruda® in adult participants with untreated metastatic non-squamous non-small cell lung cancer (NSCLC) |
Active (Recruiting) |
A Study to compare efficacy, safety, and immunogenicity of GME751 |
9 |
INSIGHT-2A
Phase II, two-arm study to investigate tepotinib combined with osimertinib in MET amplified, advanced or metastatic non-small cell lung cancer (NSCLC) harboring activating EGFR mutations and having acquired resistance to prior osimertinib therapy |
Closed |
Study to investigate tepotinib combined with osimertinib in MET amplified, advanced or metastatic non-small cell lung cancer (NSCLC) |
10 |
LAURA
A Phase III, randomized, double-blind, placebo-controlled, multicenter, international study of osimertinib as maintenance therapy in patients with locally advanced, unresectable EGFR mutation-positive on-Small Cell Lung Cancer (Stage III) whose disease has not progressed following definitive platinum-based chemoradiation therapy. |
Closed |
Study of osimertinib as maintenance therapy in patients with locally advanced |
11 |
MARIPOSA
A Randomized Study of JNJ-61186372 and Lazertinib Combination Therapy Versus Single Agent Osimertinib or Lazertinib as First-Line Treatment in Patients with EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer. |
Closed |
Study of JNJ-61186372 and Lazertinib Combination Therapy Versus Single Agent Osimertinib or Lazertinib as First-Line Treatment |
12 |
ATORG003
A single-arm, open-label, phase 2 study of Dacomitinib with or without dose titration for the first-line treatment of locally advanced or metastatic non-small cell lung cancer in subjects with an epidermal growth factor receptor (egfr) activation mutation |
Closed |
Study of Dacomitinib with or without dose titration for the first-line treatment of locally advanced |
13 |
ML41262
A Prospective, Multicentre, Genomic Profiling Study In Patients With Locally Advanced Or Metastatic Non-small Cell Lung Cancer (NSCLC) In Malaysia Using Foundation Medicine |
Closed |
|
14 |
INCMGA 0012-304
A Randomized, Double Blind, Phase 3 Study of Platinum-based Chemotherapy with or without INCMGA00012 in First-Line Metastatic Squamous and Nonsquamous Non-Small Cell Lung Cancer Participants |
Closed |
Study of Platinum-based Chemotherapy with or without INCMGA00012 |
15 |
PFIZER A7471067
Real-world utilization and outcomes with “study drug” first-line treatment for EGFR mutation-positive advanced non-small cell lung cancer among Asian patients – A multi-center chart review |
Closed |
Real-world utilization and outcomes with “study drug” first-line treatment |
16 |
MK7684A-002
“A Phase II, multicenter, randomized study to compare the efficacy and safety of MK-7684A or MK-7684A plus Docetaxel versus Docetaxel monotherapy in the treatment of participants with metastatic non-small cell lung cancer with progressive disease after treatment with a platinum doublet chemotherapy and immunotherapy” |
Closed |
Study to compare the efficacy and safety of MK-7684A or MK-7684A plus Docetaxel |
17 |
MARIPOSA2
A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure |
Closed |
A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy |
18 |
ADAURA-2
D516FC00001 – A Phase III, Double-blind, Randomized, Placebo-Controlled, International Study to assess the Efficacy and Safety of Adjuvant Osimertinib versus Placebo in Patients with EGFR mutation-positive, Stage IA2-IA3 Non-small Cell Lung Cancer, following Complete Tumor Resection |
Closed |
Study to assess the Efficacy and Safety of Adjuvant Osimertinib |
19 |
kontRASt-02
CJDQ443B12301 : A randomized, controlled, open label, phase III study evaluating the efficacy and safety of JDQ443 versus docetaxel in previously treated subjects with locally advanced or metastatic KRAS G12C mutant non-small cell lung cancer |
Closed |
A randomized, controlled, open label, phase III study evaluating the efficacy and safety of JDQ443 |